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…or n-alkanes"), or the lack of anesthesia by temperature induced re-ordering in lipids which mimics anesthetic effects therein'''. Finally, there are exceptions to the Meyer-Overton rule. Agents, such as 1,3,5 tris(trifluoromethyl)senzene (TFMB) and 1,2 dichlorohexafluorocyclobutane (F6), which are predicted by their lipid solubility to have significant anesthetic potency but do not, even at higher concentrations (represented by an estimated MAC of 1000% atmospheres (atm)) (Fig. 2A). Consequently, these agents are called non…